Institutional Repository of Xishuangbanna Tropical Botanical Garden
| Anti-Inflammatory Effects of Resveratrol and Oligostilbenes from Vitis thunbergii var. taiwaniana against Lipopolysaccharide-Induced Arthritis | |
| Wang, K. T. | |
| 2011 | |
| Source Publication | Journal of Agricultural and Food Chemistry
 |
| ISSN | 0021-8561 |
| Volume | 59Issue:8Pages:3649-3656 |
| Abstract | Vitis thunbergii Sieb. and Zucc. var. taiwaniana Lu is an endemic plant in Taiwan used as a dietary supplement for bone health. In this study, human chondrocytes were induced to produce COX-2, MMP-3, -13, and PGE(2) by LPS. An (18)F-FDG microPET imaging system was used to evaluate the anti-inflammatory arthritic effects in vivo. Six stilbenes, resveratrol (1), ()-epsilon-viniferin (2), ampelopsin C (3), ampelopsin A (4), (-)-vitisin B (5), and ()-vitisin A (6), were isolated from the stem part of V. thunbergii, which displayed the strongest PGE2 inhibition. Among these compounds, 1 significantly decreased COX-2 activity, PGE(2), MMP-3, and -13 production in vitro, and (18)F-FDG uptake and serum PGE(2) in rabbits in vivo. Anti-inflammatory effects were enhanced through the combined usage of 1 and other oligostilbenes. Taken together, the synergistic effects of 1 and oligostilbenes resulted in stem part extracts with lower 1 content displaying the better anti-inflammatory arthritis effects. |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/8569 |
| Collection | 公共技术服务中心主要仪器相关文献_植物活体成像系统 |
| Recommended Citation GB/T 7714 | Wang, K. T.. Anti-Inflammatory Effects of Resveratrol and Oligostilbenes from Vitis thunbergii var. taiwaniana against Lipopolysaccharide-Induced Arthritis[J]. Journal of Agricultural and Food Chemistry,2011,59(8):3649-3656. |
| APA | Wang, K. T..(2011).Anti-Inflammatory Effects of Resveratrol and Oligostilbenes from Vitis thunbergii var. taiwaniana against Lipopolysaccharide-Induced Arthritis.Journal of Agricultural and Food Chemistry,59(8),3649-3656. |
| MLA | Wang, K. T.."Anti-Inflammatory Effects of Resveratrol and Oligostilbenes from Vitis thunbergii var. taiwaniana against Lipopolysaccharide-Induced Arthritis".Journal of Agricultural and Food Chemistry 59.8(2011):3649-3656. |
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| Anti-Inflammatory Ef（3401KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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