| Natural Geranylated Sulfur-Containing Amides with Inhibitory Effect on Th17 Differentiation | |
Ji, Kai-Long ; Tang, Yan-Qing; Guo, Zheng-Yang; GongPan, Pian-Chou; Sun, Peng; Lu, Jian-Mei; Dai, Meng-Yuan; Li, Ting6
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| 2023 | |
| Source Publication | CHEMISTRY & BIODIVERSITY
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| ISSN | 1612-1872 |
| Volume | 20Issue:6Pages:- |
| Abstract | Chemical investigation of medicinal plant Glycosmis lucida Wall. ex C. C. Huang leaves led to the production of ten compounds (1-10), including two previously unreported geranylated sulfurcontaining amides (1 and 2) and eight known ones (3-10). Structural characterization was carried out using comprehensive spectroscopic methods including NMR, MS and CD. The inhibitory effects of all isolates on Th17 differentiation were evaluated, of which compounds 1 and 6 significantly inhibited Th17 differentiation with IC50 values of 0.36 and 1.30 mu M, respectively, while both 1 and 6 failed to bind to retinoic acid-related orphan receptor gamma t (ROR gamma t), suggesting that their inhibition of Th17 differentiation is independent of ROR gamma t. |
| Keyword | Glycosmis lucida geranylated sulfonyl amides glylucidamides Th17 differentiation ROR gamma t |
| Subject Area | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| DOI | 10.1002/cbdv.202300373 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000993358400001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/13638 |
| Collection | 2012年后新成立研究组 |
| Affiliation | 1.[Ji, Kai-Long 2.GongPan, Pian-Chou 3.Sun, Peng 4.Chinese Acad Sci, CAS Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Kunming 650223, Peoples R China 5.[Tang, Yan-Qing 6.Guo, Zheng-Yang 7.Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Macau 999078, Peoples R China 8.Yunnan Acad Agr Sci, Ind Crop Res Inst, Kunming 650223, Peoples R China |
| Recommended Citation GB/T 7714 | Ji, Kai-Long,Tang, Yan-Qing,Guo, Zheng-Yang,et al. Natural Geranylated Sulfur-Containing Amides with Inhibitory Effect on Th17 Differentiation[J]. CHEMISTRY & BIODIVERSITY,2023,20(6):-. |
| APA | Ji, Kai-Long.,Tang, Yan-Qing.,Guo, Zheng-Yang.,GongPan, Pian-Chou.,Sun, Peng.,...&Li, Ting.(2023).Natural Geranylated Sulfur-Containing Amides with Inhibitory Effect on Th17 Differentiation.CHEMISTRY & BIODIVERSITY,20(6),-. |
| MLA | Ji, Kai-Long,et al."Natural Geranylated Sulfur-Containing Amides with Inhibitory Effect on Th17 Differentiation".CHEMISTRY & BIODIVERSITY 20.6(2023):-. |
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| Natural Geranylated （1540KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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