Four new steroids from the leaves and twigs of Dysoxylum pallens and their cytotoxic activities

doi:10.1016/j.fitote.2020.104696

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	Four new steroids from the leaves and twigs of Dysoxylum pallens and their cytotoxic activities
	Wang, Jia-Nan ; Zhang, Zong-Yi ; Sun, Peng ; Cao, Dong-Hua ; Xiao, Yi-Dian ; Shi, Xiao-Cui ; Xiao, Chun-Fen ; Hu, Hua-Bin; Xu, You-Kai
	2020
Source Publication	FITOTERAPIA
ISSN	0367-326X
Volume	146 Issue:x Pages:-
Abstract	Four previously undescribed steroids, identified as (3S,7S,8S,9S,10R,13S,14S,16S,17R,20S)-7 alpha-methoxy-ergosta-5,24(28)-dien-3 beta,16 beta,20-triol (1), ergosta-5,24(28)-dien-3 beta,7 alpha,16 beta-triol (2), ergosta-5,25-dien-3 beta,7 alpha,16 beta,20-tetrol (3) and 7 alpha,16 beta,24 alpha-trihydroxy-varninasterol (4), as well as five known analogues (5-9), were isolated from the leaves and twigs of Dysoxylum pallens Hiern (Meliaceae). Their structures were elucidated based on extensive spectroscopic analysis such as HR-ESI-MS, 1D and 2D NMR, UV, and IR. The absolute configuration of compound 1 was determined by X-ray diffraction analysis. Selected compounds were evaluated for their cytotoxic activities. Compounds 1, 2, and 8 exhibited moderate cytotoxic activity against HL-60, Hela, and HepG2 tumor cell lines with IC50 ranged from 11.09 to 17.51 mu M.
Keyword	Dysoxylum pallens Hiern Meliaceae Ergosterols Cytotoxicity
Subject Area	Pharmacology & Pharmacy
DOI	10.1016/j.fitote.2020.104696
Indexed By	SCI
Language	英语
WOS ID	WOS:000580427700042
Citation statistics
Document Type	期刊论文
Identifier	https://ir.xtbg.ac.cn/handle/353005/11888
Collection	民族植物学研究组
Affiliation	1.[Wang, Jia-Nan 2.Zhang, Zong-Yi 3.Sun, Peng 4.Cao, Dong-Hua 5.Shi, Xiao-Cui 6.Xiao, Chun-Fen 7.Hu, Hua-Bin 8.Chinese Acad Sci, Key Lab Trop Plant Resources & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China 9.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 10.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 11.Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ, Kunming 650091, Yunnan, Peoples R China
Recommended Citation GB/T 7714	Wang, Jia-Nan,Zhang, Zong-Yi,Sun, Peng,et al. Four new steroids from the leaves and twigs of Dysoxylum pallens and their cytotoxic activities[J]. FITOTERAPIA,2020,146(x):-.
APA	Wang, Jia-Nan.,Zhang, Zong-Yi.,Sun, Peng.,Cao, Dong-Hua.,Xiao, Yi-Dian.,...&Xu, You-Kai.(2020).Four new steroids from the leaves and twigs of Dysoxylum pallens and their cytotoxic activities.FITOTERAPIA,146(x),-.
MLA	Wang, Jia-Nan,et al."Four new steroids from the leaves and twigs of Dysoxylum pallens and their cytotoxic activities".FITOTERAPIA 146.x(2020):-.

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