| (+/-)-Meliviticines A and B: Rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity | |
Li, Wei2; Rao, Li; Liu, Yu; He, Qian; Fan, Yue; You, Yun-Xia; Su, Yu; Hu, Feng; Xu, You-Kai ; Lin, Bin4; Yin, Sheng2; Zhang, Chuan-Rui
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| 2019 | |
| Source Publication | BIOORGANIC CHEMISTRY
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| ISSN | 0045-2068 |
| Volume | 90Issue:xPages:- |
| Abstract | Two new prenylated acetophenone derivatives racemates, meliviticines A (1) and B (2) with unprecedented rearranged skeletons, were isolated from Melicope viticina. Subsequent chiral resolution led to the separation of two pairs of enantiomers, (+/-)-meliviticines A (1a/1b) and (+/-)-meliviticines B (2a/2b). Their structures including absolute configurations were elucidated by extensive spectroscopic data, electronic circular dichroism analysis, and X-ray crystallography. A plausible biosynthetic pathway of 1 and 2, involving ring cleavage and rearrangement of the prenylated acetophenone backbone was proposed. All the isolates showed moderate antimicrobial activities with MIC values of 25-50 mu g/mL against several bacterial and fungal strains. |
| Keyword | Melicope viticina Prenylated acetophenone derivatives Absolute configuration Antimicrobial activity |
| Subject Area | Biochemistry & Molecular Biology ; Chemistry |
| DOI | 10.1016/j.bioorg.2019.103099 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000479184600031 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/11460 |
| Collection | 民族植物学研究组 |
| Affiliation | 1.Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China 2.Chongqing Univ, Sch Pharmaceut Sci, Chem Biol Res Ctr, Chongqing 401331, Peoples R China 3.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China 4.Chinese Acad Sci, Key Lab Trop Plant Resource & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Yunnan, Peoples R China 5.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China |
| Recommended Citation GB/T 7714 | Li, Wei,Rao, Li,Liu, Yu,et al. (+/-)-Meliviticines A and B: Rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity[J]. BIOORGANIC CHEMISTRY,2019,90(x):-. |
| APA | Li, Wei.,Rao, Li.,Liu, Yu.,He, Qian.,Fan, Yue.,...&Zhang, Chuan-Rui.(2019).(+/-)-Meliviticines A and B: Rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity.BIOORGANIC CHEMISTRY,90(x),-. |
| MLA | Li, Wei,et al."(+/-)-Meliviticines A and B: Rearranged prenylated acetophenone derivatives from Melicope viticina and their antimicrobial activity".BIOORGANIC CHEMISTRY 90.x(2019):-. |
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| (?)-Meliviticines A （1431KB） | 期刊论文 | 作者接受稿 | 开放获取 | CC BY-NC-SA | View Download | |
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