| Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae | |
| Bing Liu; You-Kai Xu | |
| 2016 | |
| Source Publication | Natural Product Research
 |
| Volume | 30Issue:4Pages:433-437 |
| Abstract | Twelve compounds were isolated from the roots of Aglaia odorata. Their structures were established on the basis of NMR and MS data as rocaglaol (1), rocaglamide (2), eichlerialactone (3), sapelins A (4), isofouquierone (5), eichlerianic acid (6), shoreic acid (7), agladupol E (8), 3-epimeliantriol (9), cleomiscosins B (10), 2β,3β-dihydroxy-5α-pregnane-16-one (11) and β-d-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (12). Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007–0.095 μM, while compounds 3–5 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values >40 μM). Compound 6 showed only weak cytotoxicity (IC50 6.87 to >40 μM) and its epmier7 was completely inactivite (IC50>40 μM) in the assay. However, potent synergistic effect was observed when the molar ratio of 6 to 7 is between 4:1 and 1:1. |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/9887 |
| Collection | 民族植物学研究组 |
| Recommended Citation GB/T 7714 | Bing Liu,You-Kai Xu. Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae[J]. Natural Product Research,2016,30(4):433-437. |
| APA | Bing Liu,&You-Kai Xu.(2016).Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae.Natural Product Research,30(4),433-437. |
| MLA | Bing Liu,et al."Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae".Natural Product Research 30.4(2016):433-437. |
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