Institutional Repository of Xishuangbanna Tropical Botanical Garden
| Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus | |
| Huang, Shan-Shan; Jian, Kai-Li; Li, Rui-Jun; Kong, Ling-Yi; Yang, Ming-Hua | |
| 2016 | |
| Source Publication | RSC ADVANCES
 |
| ISSN | 2046-2069 |
| Volume | 6Issue:8Pages:6320-6328 |
| Abstract | Six phytosteroids and three dammarane-type triterpenoids, namely chisopanoids A-F (1-6) and chisopanones G-I (7-9), together with nine known triterpenoids (10-18) were isolated from the leaves of Chisocheton cumingianus. Their structures were elucidated by extensive spectroscopic analysis, X-ray crystallographic analysis, Mosher's method and Mo-2(OAc)(4)-induced electronic circular dichroism (ECD) data. All compounds were evaluated for their cytotoxicities against HepG2, U2OS and MCF-7 human cancer cell lines, as well as inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages. Compounds 5 and 6 showed potent cytotoxicities towards MCF-7 with IC50 values of 3.24 /- 1.39 and 8.85 /- 4.73 mu M, and were further proved to inhibit the cell proliferation mainly by inducing apoptosis. |
| Keyword | Absolute-configuration Dammarane Triterpenes Oxidation-products Constituents |
| Indexed By | SCI |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/9799 |
| Collection | 文献共享 |
| Recommended Citation GB/T 7714 | Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,et al. Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus[J]. RSC ADVANCES,2016,6(8):6320-6328. |
| APA | Huang, Shan-Shan,Jian, Kai-Li,Li, Rui-Jun,Kong, Ling-Yi,&Yang, Ming-Hua.(2016).Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus.RSC ADVANCES,6(8),6320-6328. |
| MLA | Huang, Shan-Shan,et al."Phytosteroids and triterpenoids with potent cytotoxicities from the leaves of Chisocheton cumingianus".RSC ADVANCES 6.8(2016):6320-6328. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Phytosteroids and tr（670KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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