Institutional Repository of Xishuangbanna Tropical Botanical Garden
| Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2 | |
| Cheng, YB; Chien, YT; Lee, JC; Tseng, CK; Wang, HC; Lo, IW; Wu, YH; Wang, SY; Wu, YC; Chang, FR | |
| 2014 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| Volume | 77Issue:11Pages:2367-2374 |
| Abstract | Fractionation of an ethanol-soluble extract of the seeds of Swietenia macrophylla yielded six new limonoids, swielimonoids A-F (1-6), along with 20 known compounds. Compounds 1 and 2, mexicanolide-type limonoids, were assigned with an alpha,beta-unsaturated d-lactone moiety (ring D) and a C-C bond between C-8 and C-30. Compounds 3-6 could be categorized as highly oxygenated phragmalin-type limonoids. The structures of these new compounds were elucidated through the interpretation of spectroscopic data. The antidengue virus 2 activities of the isolated components from S. macrophylla were investigated, and of 12 compounds subjected to bioassay, compounds 2 and 7-10 were found to show inhibitory activity in the range 3.5 to 12.5 mu M. Among these, the new limonoid 2 exhibited significant antiviral activity (EC50 = 7.2 /- 1.33 mu M) with a selectivity index (CC50/EC50) value of >27.7. |
| Keyword | Diabetic-rats Mahagoni Jacq Constituents Orthoesters Meliaceae Extracts Mahogani Twigs |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/9111 |
| Collection | 文献共享 |
| Recommended Citation GB/T 7714 | Cheng, YB,Chien, YT,Lee, JC,et al. Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2[J]. JOURNAL OF NATURAL PRODUCTS,2014,77(11):2367-2374. |
| APA | Cheng, YB.,Chien, YT.,Lee, JC.,Tseng, CK.,Wang, HC.,...&Chang, FR.(2014).Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2.JOURNAL OF NATURAL PRODUCTS,77(11),2367-2374. |
| MLA | Cheng, YB,et al."Limonoids from the Seeds of Swietenia macrophylla with Inhibitory Activity against Dengue Virus 2".JOURNAL OF NATURAL PRODUCTS 77.11(2014):2367-2374. |
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| File Name/Size | DocType | Version | Access | License | ||
| Limonoids from the S（787KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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