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| Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis | |
| Fan, YY; Zhang, H; Zhou, Y; Liu, HB; Tang, W; Zhou, B; Zuo, JP; Yue, JM | |
| 2015 | |
| Source Publication | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| ISSN | 0002-7863 |
| Volume | 137Issue:1Pages:138-141 |
| Abstract | Phainanoids A-F (1-6), six highly modified triterpenoids with a new carbon skeleton by incorporating two unique motifs of a 4,5- and a 5,5-spirocyclic systems, were isolated from Phyllanthus hainanensis. Their structures with absolute configurations were determined by spectroscopic data, chemical methods, and X-ray crystallography. Compounds 1-6 exhibited exceptionally potent immunosuppressive activities in vitro against the proliferation of T and B lymphocytes. The most potent one, phainanoid F (6), showed activities against the proliferation of T cells with IC50 value of 2.04 /- 0.01 nM (positive control CsA = 14.21 /- 0.01 nM) and B cells with IC50 value of <1.60 /- 0.01 nM (CsA = 352.87 /- 0.01 nM), which is about 7 and 221 times as active as CsA, respectively. The structure-activity relationships of 1-6 are discussed. |
| Keyword | Karplus Equation Hydrogen-bond Ivorenolide Derivatives Macrolide Peptides |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/9105 |
| Collection | 文献共享 |
| Recommended Citation GB/T 7714 | Fan, YY,Zhang, H,Zhou, Y,et al. Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2015,137(1):138-141. |
| APA | Fan, YY.,Zhang, H.,Zhou, Y.,Liu, HB.,Tang, W.,...&Yue, JM.(2015).Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,137(1),138-141. |
| MLA | Fan, YY,et al."Phainanoids A-F, A New Class of Potent Immunosuppressive Triterpenoids with an Unprecedented Carbon Skeleton from Phyllanthus hainanensis".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 137.1(2015):138-141. |
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| File Name/Size | DocType | Version | Access | License | ||
| Phainanoids A-F, A N（2482KB） | 开放获取 | CC BY-NC-SA | View Download | |||
| Phainanoids A–F, A N（667KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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