Institutional Repository of Xishuangbanna Tropical Botanical Garden
| Antichlamydial Sterol from the Red Sea Sponge Callyspongia aff. implexa | |
| Abdelmohsen, UR; Cheng, C; Reimer, A; Kozjak-Pavlovic, V; Ibrahim, AK; Rudel, T; Hentschel, U; Edrada-Ebel, R; Ahmed, SA | |
| 2015 | |
| Source Publication | PLANTA MEDICA
 |
| ISSN | 0032-0943 |
| Volume | 81Issue:5Pages:382-387 |
| Abstract | Marine sponges are rich sources of natural products exhibiting diverse biological activities. Bioactivity-guided fractionation of the Red Sea sponge Callyspongia aff. implexa led to the isolation of two new compounds, 26,27-bisnorcholest-5,16-dien-23-yn-3 beta, 7 alpha-diol, gelliusterol E (1) and C-27-polyacetylene, callimplexen A (2), in addition to the known compound beta-sitosterol (3). The structures of the isolated compounds were determined by 1D- and 2D-NMR techniques as well as high-resolution tandem mass spectrometry and by comparison to the literature. The three compounds (1-3) were tested against Chlamydia trachomatis, an obligate intracellular gram-negative bacterium, which is the leading cause of ocular and genital infections worldwide. Only gelliusterol E (1) inhibited the formation and growth of chlamydial inclusions in a dose-dependent manner with an IC50 value of 2.3 mu M. |
| Keyword | Marine Natural-products Chlamydia-trachomatis Secondary Metabolites Antifouling Activity Paradigm Pathogenesis Derivatives Resistance Truncata Drugs |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/9093 |
| Collection | 文献共享 |
| Recommended Citation GB/T 7714 | Abdelmohsen, UR,Cheng, C,Reimer, A,et al. Antichlamydial Sterol from the Red Sea Sponge Callyspongia aff. implexa[J]. PLANTA MEDICA,2015,81(5):382-387. |
| APA | Abdelmohsen, UR.,Cheng, C.,Reimer, A.,Kozjak-Pavlovic, V.,Ibrahim, AK.,...&Ahmed, SA.(2015).Antichlamydial Sterol from the Red Sea Sponge Callyspongia aff. implexa.PLANTA MEDICA,81(5),382-387. |
| MLA | Abdelmohsen, UR,et al."Antichlamydial Sterol from the Red Sea Sponge Callyspongia aff. implexa".PLANTA MEDICA 81.5(2015):382-387. |
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| File Name/Size | DocType | Version | Access | License | ||
| Antichlamydial Stero（196KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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