| Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid | |
Zhang, W; Cao, SN; Qiu, L; Qi, FX; Li, Z; Yang, Y; Huang, SH; Bai, FL; Liu, CN ; Wan, XB; Li, SY
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| 2015 | |
| Source Publication | CHEMBIOCHEM
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| ISSN | 1439-4227 |
| Volume | 16Issue:4Pages:565-569 |
| Abstract | Mycophenolic acid (MPA, 1) is a clinically important immunosuppressant. In this report, a gene cluster mpa responsible for the biosynthesis of 1 was identified from Penicillium brevicompactum NRRL 864. The S-adenosyl-L-methionine-dependent (SAM-dependent) O-methyltransferase encoded by the mpaG gene was functionally and kinetically characterized in vitro. MpaG catalyzes the methylation of demethylmycophenolic acid (DMMPA, 6) to form 1. It also showed significant substrate flexibility by methylating two structural derivatives of 6 prepared by organic synthesis. |
| Keyword | Biosynthesis Methyltransferases Mycophenolic Acid Substrate Flexibility Transferases |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/8682 |
| Collection | 其他 2012年后新成立研究组 |
| Recommended Citation GB/T 7714 | Zhang, W,Cao, SN,Qiu, L,et al. Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid[J]. CHEMBIOCHEM,2015,16(4):565-569. |
| APA | Zhang, W.,Cao, SN.,Qiu, L.,Qi, FX.,Li, Z.,...&Li, SY.(2015).Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid.CHEMBIOCHEM,16(4),565-569. |
| MLA | Zhang, W,et al."Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid".CHEMBIOCHEM 16.4(2015):565-569. |
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