| Isolation, Anti-TMV Activity, and Modes of Action of Novel Isochromene and Isoquinoline Derivatives from Streptomyces mirabilis YMZU50 | |
| Yang, Feng-Xian; Liu, Hua-Yin; Zhang, Yan-Qun; Pu, Gui; Zhang, Rong; Li, Jin5; Yang, Guang-Yu; Zhang, Yu-Mei; Hu, Qiu-Fen | |
| 2025 | |
| Source Publication | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
 |
| ISSN | 0021-8561 |
| Volume | 73Issue:32Pages:20205-20218 |
| Abstract | Fourteen compounds, including three new isochromenes (1-3) and four new isoquinolines (4-7), were isolated from Streptomyces mirabilis YMZU50. The anti-tobacco mosaic virus (TMV) activities of compounds 1-8 and 13 were evaluated. Compound 6 exhibited the strongest inactivation and protective effects, with inhibition rates of 76.8 and 80.2%, respectively, surpassing the positive control ningnanmycin (45.8 and 43.6%). It also demonstrated curative effects in mildly (grades 1-3) and severely (grade 9) infected plants, reducing severity to grades 1 and 3, respectively. Transmission electron microscopy (TEM) observations confirmed a direct viral particle disruption. Physiological and biochemical analyses revealed a significant enhancement of defense-related enzymes and salicylic acid (SA)accumulation in tobacco. Transcriptomic profiling indicated strong upregulation of photosynthesis-related genes, while metabolomic analysis revealed changes in defense-associated metabolites. These results demonstrate compound 6 as a promising eco-friendly antiviral agent with multimodal TMV control mechanisms, underscoring the potential of Streptomyces-derived products for sustainable crop protection. |
| Keyword | isochromene isoquinoline Streptomyces anti-TMV activity modes of action |
| Subject Area | Agriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology |
| DOI | 10.1021/acs.jafc.5c04388 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:001543663900001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/15637 |
| Collection | 2012年后新成立研究组 |
| Affiliation | 1.[Yang, Feng-Xian 2.Liu, Hua-Yin 3.Pu, Gui 4.Chinese Acad Sci, Xishuangbanna Trop Bot Garden, Kunming 650223, Peoples R China 5.Zhang, Rong 6.China Tobacco Yunnan Ind Co Ltd, Yunnan Key Lab Tobacco Chem, Kunming 650231, Peoples R China 7.[Liu, Hua-Yin 8.Zhang, Yan-Qun 9.Yang, Guang-Yu 10.Yunnan Minzu Univ, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650500, Peoples R China 11.Yunnan Minzu Univ, Minist Educ, Kunming 650500, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Feng-Xian,Liu, Hua-Yin,Zhang, Yan-Qun,et al. Isolation, Anti-TMV Activity, and Modes of Action of Novel Isochromene and Isoquinoline Derivatives from Streptomyces mirabilis YMZU50[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2025,73(32):20205-20218. |
| APA | Yang, Feng-Xian.,Liu, Hua-Yin.,Zhang, Yan-Qun.,Pu, Gui.,Zhang, Rong.,...&Hu, Qiu-Fen.(2025).Isolation, Anti-TMV Activity, and Modes of Action of Novel Isochromene and Isoquinoline Derivatives from Streptomyces mirabilis YMZU50.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,73(32),20205-20218. |
| MLA | Yang, Feng-Xian,et al."Isolation, Anti-TMV Activity, and Modes of Action of Novel Isochromene and Isoquinoline Derivatives from Streptomyces mirabilis YMZU50".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 73.32(2025):20205-20218. |
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