| Indole alkaloids from Uncaria rhynchophylla and their inhibitory activities against α-glucosidase | |
| Huang, Kepu1,2; Chen, Xuelin3; Li, Sheng; Zhang, Xinjian; Zhang, Yumei3; Zhang, Yu3 | |
| 2025 | |
| Source Publication | PHYTOCHEMISTRY
 |
| ISSN | 0031-9422 |
| Volume | 236Issue:xPages:- |
| Abstract | Sixteen indole alkaloids were isolated from the hook-bearing stems of Uncaria rhynchophylla (Rubiaceae family), including seven undescribed ones, uncarialines F-L (1-5, 7, and 8), and a naturally occurring alkaloid, 3-epicorynanthine (6). Among them, alkaloids 1 and 2 were identified as rare quaternary ammonium alkaloids, and alkaloid 7 exhibited an unprecedented indole alkaloid framework. Their structures were characterized by a comprehensive analysis of NMR, MS, ECD and single-crystal X-ray diffraction. Notably, alkaloid 5 demonstrate potent inhibitory activity against alpha-glucosidase, with an IC50 value of 18.45 +/- 0.77 mu M. Furthermore, the inhibitory kinetics of alpha-glucosidase revealed that alkaloid 5 belong to the mix inhibition type. Molecular docking analysis showed that alkaloid 5 possessed superior binding affinity with alpha-glucosidase (-10.7 kcal/mol). |
| Keyword | Uncaria rhynchophylla Rubiaceae Uncarialines F -L Quaternary ammonium alkaloid alpha-Glucosidase |
| Subject Area | Biochemistry & Molecular Biology ; Plant Sciences |
| DOI | 10.1016/j.phytochem.2025.114490 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:001461350900001 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/14686 |
| Collection | 2012年后新成立研究组 |
| Affiliation | 1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Nat Med, Kunming 650201, Peoples R China 2.Kunming Med Univ, Sch Pharmaceut Sci, Kunming 650500, Peoples R China 3.Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Peoples R China 4.Chinese Acad Sci, Xishuangbanna Trop Bot Garden, Key Lab Trop Plant Resource & Sustainable Use, Kunming 650223, Peoples R China |
| Recommended Citation GB/T 7714 | Huang, Kepu,Chen, Xuelin,Li, Sheng,et al. Indole alkaloids from Uncaria rhynchophylla and their inhibitory activities against α-glucosidase[J]. PHYTOCHEMISTRY,2025,236(x):-. |
| APA | Huang, Kepu,Chen, Xuelin,Li, Sheng,Zhang, Xinjian,Zhang, Yumei,&Zhang, Yu.(2025).Indole alkaloids from Uncaria rhynchophylla and their inhibitory activities against α-glucosidase.PHYTOCHEMISTRY,236(x),-. |
| MLA | Huang, Kepu,et al."Indole alkaloids from Uncaria rhynchophylla and their inhibitory activities against α-glucosidase".PHYTOCHEMISTRY 236.x(2025):-. |
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| Indole alkaloids fro（4049KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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