| New bioactive peptides from the venom gland of a social hornet Vespa velutina | |
Meng, Yi-Chuan; Mo, Xiang-Gui; He, Tian-Tian; Wen, Xin-Xin; Nieh, James-C; Yang, Xin-Wang; Tan, Ken3
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| 2021 | |
| Source Publication | TOXICON
 |
| ISSN | 0041-0101 |
| Volume | 199Issue:xPages:94-100 |
| Abstract | Bacterial resistance to drugs is a global problem requiring the urgent development of new antibiotics. Antimicrobial peptides (AMPs) are excellent candidates for the design of novel antibiotics to combat microbial resistance. In this research, we identified four new peptides (U-VVTX-Vp1a, U-VVTX-Vp1b, U-VVTX-Vp2a, and UVVTX-Vp2b, respectively) from the venom of Vespa velutina, and tested their antimicrobial, antioxidant, and hemolytic effects. All four peptides showed scavenging ability against DPPH, ABTS+, and center dot OH free radicals. Of note, Vp1b strongly inhibited the growth of Staphylococcus aureus and Escherichia coli bacteria at concentrations of 60 and 120 mu M. Due to their low hemolytic activity, all four peptides could be utilized in the development of new antioxidants and as candidates for the design of novel antimicrobial agents. |
| Keyword | Vespa velutina Venom gland Antimicrobial peptides Antioxidative peptides |
| Subject Area | Pharmacology & Pharmacy ; Toxicology |
| DOI | 10.1016/j.toxicon.2021.06.002 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000675540600004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/12321 |
| Collection | 2012年后新成立研究组 |
| Affiliation | 1.[Meng, Yi-Chuan 2.Mo, Xiang-Gui 3.Wen, Xin-Xin 4.Chinese Acad Sci, CAS Key Lab Trop Forest Ecol, Xishuangbanna Trop Bot Garden, Kunming 650000, Yunnan, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.[He, Tian-Tian 7.Kunming Med Univ, Fac Basic Med Sci, Dept Anat & Histol & Embryol, Kunming 650500, Yunnan, Peoples R China 8.Univ Calif San Diego, Div Biol Sci, Sect Ecol Behav & Evolut, La Jolla, CA 92093 USA |
| Recommended Citation GB/T 7714 | Meng, Yi-Chuan,Mo, Xiang-Gui,He, Tian-Tian,et al. New bioactive peptides from the venom gland of a social hornet Vespa velutina[J]. TOXICON,2021,199(x):94-100. |
| APA | Meng, Yi-Chuan.,Mo, Xiang-Gui.,He, Tian-Tian.,Wen, Xin-Xin.,Nieh, James-C.,...&Tan, Ken.(2021).New bioactive peptides from the venom gland of a social hornet Vespa velutina.TOXICON,199(x),94-100. |
| MLA | Meng, Yi-Chuan,et al."New bioactive peptides from the venom gland of a social hornet Vespa velutina".TOXICON 199.x(2021):94-100. |
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| New bioactive peptid（5102KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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