| Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses | |
| Zhou, Hong; Ji, Jingkai; Chen, Xing; Bi, Yuhai2; Li, Juan; Wang, Qihui2; Hu, Tao; Song, Hao3; Zhao, Runchu2,4; Chen, Yanhua; Cui, Mingxue; Zhang, Yanyan; Hughes, Alice C.; Holmes, Edward C.; Shi, Weifeng8 | |
| 2021 | |
| Source Publication | CELL
 |
| ISSN | 0092-8674 |
| Volume | 184Issue:17Pages:4380-+ |
| Abstract | Despite the discovery of animal coronaviruses related to SARS-CoV-2, the evolutionary origins of this virus are elusive. We describe a meta-transcriptomic study of 411 bat samples collected from a small geographical region in Yunnan province, China, between May 2019 and November 2020. We identified 24 full-length coronavirus genomes, including four novel SARS-CoV-2-related and three SARS-CoV-related viruses. Rhinolophus pusillus virus RpYN06 was the closest relative of SARS-CoV-2 in most of the genome, although it possessed a more divergent spike gene. The other three SARS-CoV-2-related coronaviruses carried a genetically distinct spike gene that could weakly bind to the hACE2 receptor in vitro. Ecological modeling predicted the co-existence of up to 23 Rhinolophus bat species, with the largest contiguous hot-spots extending from South Laos and Vietnam to southern China. Our study highlights the remarkable diversity of bat coronaviruses at the local scale, including close relatives of both SARS-CoV-2 and SARS-CoV. |
| Subject Area | Biochemistry & Molecular Biology ; Cell Biology |
| DOI | 10.1016/j.cell.2021.06.008 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000686554600004 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/12308 |
| Collection | 2012年后新成立研究组 |
| Affiliation | 1.Shandong First Med Univ & Shandong Acad Med Sci, Key Lab Etiol & Epidemiol Emerging Infect Dis Uni, Tai An 271000, Shandong, Peoples R China 2.Chen, Xing; Chen, Yanhua; Hughes, Alice C.] Chinese Acad Sci, Ctr Integrat Conservat, Landscape Ecol Grp, Xishuangbanna Trop Bot Garden, Mengla 666303, Yunnan, Peoples R China 3.Chinese Acad Sci, CAS Ctr Influenza Res & Early Warning CASCIRE, CAS TWAS Ctr Excellence Emerging Infect Dis CEEID, Inst Microbiol,CAS Key Lab Pathogen Microbiol & I, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Beijing Inst Life Sci, Res Network Immun & Hlth RNIH, Beijing 100101, Peoples R China 5.Anhui Univ, Inst Phys Sci & Informat, Hefei 230039, Peoples R China 6.Hughes, Alice C.] Chinese Acad Sci, Ctr Conservat Biol, Core Bot Gardens, Mengla 666303, Yunnan, Peoples R China 7.Holmes, Edward C.] Univ Sydney, Sch Life & Environm Sci, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia 8.Holmes, Edward C.] Univ Sydney, Sch Med Sci, Sydney, NSW 2006, Australia 9.Shandong First Med Univ & Shandong Acad Med Sci, Sch Publ Hlth, Tai An 271000, Shandong, Peoples R China |
| Recommended Citation GB/T 7714 | Zhou, Hong,Ji, Jingkai,Chen, Xing,et al. Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses[J]. CELL,2021,184(17):4380-+. |
| APA | Zhou, Hong.,Ji, Jingkai.,Chen, Xing.,Bi, Yuhai.,Li, Juan.,...&Shi, Weifeng.(2021).Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses.CELL,184(17),4380-+. |
| MLA | Zhou, Hong,et al."Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses".CELL 184.17(2021):4380-+. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Identification of no（10479KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment