| Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Cinnamomum bejolghota Confirm Its Functional Food Property | |
Rao, Li; You, Yun-Xia; Su, Yu; Fan, Yue; Liu, Yu; He, Qian; Chen, Yi; Meng, Jie; Hu, Lin; Li, Yizhou; Xu, You-Kai ; Lin, Bin4; Zhang, Chuan-Rui
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| 2020 | |
| Source Publication | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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| ISSN | 0021-8561 |
| Volume | 68Issue:33Pages:8825-8835 |
| Abstract | In the aim to evaluate the functional food property of Cinnamomum bejolghota, seven new lignans and neolignans, bejolghotins A-G (1-4 and 9-11), along with 14 known ones (5-8 and 12-21), were isolated and their structures including absolute configurations were elucidated by extensive spectroscopic data and electronic circular dichroism (ECD) analyses. All of the isolates were tested for antioxidant and human cancer cell proliferation inhibitory activities. Twenty compounds showed comparable antioxidant activity to the positive controls, and three significantly inhibited the growth of three cancer cell lines HCT-116, A549, and MDA-MB-231 with IC50 values of 0.78-2.93 mu M, which confirmed its health benefits. |
| Keyword | Cinnamomum bejolghota lignans neolignans antioxidant activity human cancer cell proliferation inhibition |
| Subject Area | Agriculture ; Chemistry ; Food Science & Technology |
| DOI | 10.1021/acs.jafc.0c02885 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000563071500007 |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/11782 |
| Collection | 民族植物学研究组 |
| Affiliation | 1.Chongqing Univ, Chongqing Key Lab Nat Prod Synth & Drug Res, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China 2.Chongqing Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China 3.China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Peoples R China 4.Chinese Acad Sci, Key Lab Trop Plant Resource & Sustainable Use, Xishuangbanna Trop Bot Garden, Menglun 666303, Peoples R China 5.Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China |
| Recommended Citation GB/T 7714 | Rao, Li,You, Yun-Xia,Su, Yu,et al. Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Cinnamomum bejolghota Confirm Its Functional Food Property[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2020,68(33):8825-8835. |
| APA | Rao, Li.,You, Yun-Xia.,Su, Yu.,Fan, Yue.,Liu, Yu.,...&Zhang, Chuan-Rui.(2020).Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Cinnamomum bejolghota Confirm Its Functional Food Property.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,68(33),8825-8835. |
| MLA | Rao, Li,et al."Lignans and Neolignans with Antioxidant and Human Cancer Cell Proliferation Inhibitory Activities from Cinnamomum bejolghota Confirm Its Functional Food Property".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 68.33(2020):8825-8835. |
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| Lignans and Neoligna（558KB） | 期刊论文 | 出版稿 | 开放获取 | CC BY-NC-SA | View Download | |
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