| Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae) | |
Liu, Bing; Xu, You-Kai
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| 2016 | |
| Source Publication | NATURAL PRODUCT RESEARCH
 |
| ISSN | 1478-6419 |
| Volume | 30Issue:4Pages:433-437 |
| Abstract | Twelve compounds were isolated from the roots of Aglaia odorata. Their structures were established on the basis of NMR and MS data as rocaglaol (1), rocaglamide (2), eichlerialactone (3), sapelins A (4), isofouquierone (5), eichlerianic acid (6), shoreic acid (7), agladupol E (8), 3-epimeliantriol (9), cleomiscosins B (10), 2 beta,3 beta-dihydroxy-5 alpha-pregnane-16-one (11) and beta-D-glucopyranos-1-yl N-methylpyrrole-2-carboxylate (12). Among them, compounds 1 and 2 showed significant cytotoxicity against human cancer cell (HL-60, SMMC-7721, A-549, MCF-7 and SW480) with IC50 values of 0.007-0.095 mu M, while compounds 3-5 and 10 and 11 showed moderate to no cytotoxicity (IC50 0.43 to values >40 mu M). Compound 6 showed only weak cytotoxicity (IC50 6.87 to >40 mu M) and its epmier 7 was completely inactivite (IC50 >40 mu M) in the assay. However, potent synergistic effect was observed when the molar ratio of 6 to 7 is between 4: 1 and 1:1. |
| Subject Area | Chemistry ; Pharmacology & Pharmacy |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/10441 |
| Collection | 民族植物学研究组 |
| Corresponding Author | Xu, You-Kai |
| Recommended Citation GB/T 7714 | Liu, Bing,Xu, You-Kai. Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae)[J]. NATURAL PRODUCT RESEARCH,2016,30(4):433-437. |
| APA | Liu, Bing,&Xu, You-Kai.(2016).Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae).NATURAL PRODUCT RESEARCH,30(4),433-437. |
| MLA | Liu, Bing,et al."Cytotoxicity and Synergistic Effect of the Constituents from Roots of Aglaia odorata (Meliaceae)".NATURAL PRODUCT RESEARCH 30.4(2016):433-437. |
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