Institutional Repository of Xishuangbanna Tropical Botanical Garden
| Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS) | |
| Baell, JB | |
| 2016 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| Volume | 79Issue:3Pages:616-628 |
| Abstract | We have previously reported on classes of compounds that can interfere with bioassays via a number of different mechanisms and termed such compounds Pan Assay INterference compoundS, or PAINS. These compounds were defined on the basis of high-throughput data derived from vendor-supplied synthetics. The question therefore arises whether the concept of PAINS is relevant to compounds of natural origin. Here, it is shown that this is indeed the case, but that the context of the biological readout is an important factor that must be brought into consideration. |
| Keyword | Potassium Channel Kv1.3 Clinical-trials Crystal-structure Toxicological Evaluation Chemical-properties Reactive Compounds Molecular-basis Vitamin-k Discovery Inhibitors |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/10220 |
| Collection | 文献共享 |
| Recommended Citation GB/T 7714 | Baell, JB. Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(3):616-628. |
| APA | Baell, JB.(2016).Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS).JOURNAL OF NATURAL PRODUCTS,79(3),616-628. |
| MLA | Baell, JB."Feeling Nature's PAINS: Natural Products, Natural Product Drugs, and Pan Assay Interference Compounds (PAINS)".JOURNAL OF NATURAL PRODUCTS 79.3(2016):616-628. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Feeling Nature’s PAI（1192KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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