Institutional Repository of Xishuangbanna Tropical Botanical Garden
| Counting on natural products for drug design | |
| Rodrigues, T; Reker, D; Schneider, P; Schneider, G | |
| 2016 | |
| Source Publication | NATURE CHEMISTRY
 |
| ISSN | 1755-4330 |
| Volume | 8Issue:6Pages:531-541 |
| Abstract | Natural products and their molecular frameworks have a long tradition as valuable starting points for medicinal chemistry and drug discovery. Recently, there has been a revitalization of interest in the inclusion of these chemotypes in compound collections for screening and achieving selective target modulation. Here we discuss natural-product-inspired drug discovery with a focus on recent advances in the design of synthetically tractable small molecules that mimic nature's chemistry. We highlight the potential of innovative computational tools in processing structurally complex natural products to predict their macromolecular targets and attempt to forecast the role that natural-product-derived fragments and fragment-like natural products will play in next-generation drug discovery. |
| Keyword | Catalytic Enantioselective Synthesis Inspired Compound Collection Diversity-oriented Synthesis Relevant Chemical Space Target Prediction Macromolecular Targets Combinatorial Library Network Pharmacology Medicinal Chemistry Ligand Discovery |
| Indexed By | WOS:000376529000007 |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/10217 |
| Collection | 文献共享 |
| Recommended Citation GB/T 7714 | Rodrigues, T,Reker, D,Schneider, P,et al. Counting on natural products for drug design[J]. NATURE CHEMISTRY,2016,8(6):531-541. |
| APA | Rodrigues, T,Reker, D,Schneider, P,&Schneider, G.(2016).Counting on natural products for drug design.NATURE CHEMISTRY,8(6),531-541. |
| MLA | Rodrigues, T,et al."Counting on natural products for drug design".NATURE CHEMISTRY 8.6(2016):531-541. |
| Files in This Item: | Download All | |||||
| File Name/Size | DocType | Version | Access | License | ||
| Counting on natural （812KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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