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| Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae | |
| Liu, L; Han, Y; Xiao, JH; Li, L; Guo, LD; Jiang, XJ; Kong, LY; Che, YS | |
| 2016 | |
| Source Publication | JOURNAL OF NATURAL PRODUCTS
 |
| ISSN | 0163-3864 |
| Volume | 79Issue:10Pages:2616-2623 |
| Abstract | Chlorotheolides A (1) and B (2), two new spiroketals possessing the unique [4,7]methanochromene and dispirotrione skeletons, respectively, and their putative biosynthetic precursors, 1-undecen-2,3-dicarboxylic acid (3) and maldoxin (4), were isolated from the solid substrate fermentation of the plant endophytic fungus Pestalotiopsis theae (N635). Their structures were elucidated based on NMR spectroscopic data and electronic circular dichroism calculations. Biogenetically, compounds 1 and 2 could be generated from the co-isolated 3 and 4 via Diels Alder reactions. Chlorotheolide (2) showed an antiproliferative effect against the human tumor cell line HeLa and induced an autophagic process in the cells. |
| Keyword | 42 Cycloaddition Organic-synthesis Natural-products Diels-alderase Chloropupukeananin Biosynthesis Chemistry Maldoxin Biology Fici |
| Language | 英语 |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/10212 |
| Collection | 文献共享 |
| Recommended Citation GB/T 7714 | Liu, L,Han, Y,Xiao, JH,et al. Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae[J]. JOURNAL OF NATURAL PRODUCTS,2016,79(10):2616-2623. |
| APA | Liu, L.,Han, Y.,Xiao, JH.,Li, L.,Guo, LD.,...&Che, YS.(2016).Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae.JOURNAL OF NATURAL PRODUCTS,79(10),2616-2623. |
| MLA | Liu, L,et al."Chlorotheolides A and B, Spiroketals Generated via Diets-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae".JOURNAL OF NATURAL PRODUCTS 79.10(2016):2616-2623. |
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| Chlorotheolides A an（2308KB） | 开放获取 | CC BY-NC-SA | View Download | |||
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