| Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera | |
Gong, Zhiwen; Wang, Chao; Nieh, James C.; Tan, Ken
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| 2016 | |
| Source Publication | JOURNAL OF INSECT PHYSIOLOGY
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| Volume | 90Issue:xPages:43-48 |
| Abstract | DNA methylation plays a key role in invertebrate acquisition and extinction memory. Honey bees have excellent olfactory learning, but the role of DNA methylation in memory formation has, to date, only been studied in Apis mellifera. We inhibited DNA methylation by inhibiting DNA methyltransferase (DNMT) with zebularine (zeb) and studied the resulting effects upon olfactory acquisition and extinction memory in two honey bee species, Apis cerana and A. mellifera. We used the proboscis extension reflex (PER) assay to measure memory. We provide the first demonstration that DNA methylation is also important in the olfactory extinction learning of A. cerana. DNMT did not reduce acquisition learning in either species. However, zeb bidirectionally and differentially altered extinction learning in both species. In particular, zeb provided 1 h before acquisition learning improved extinction memory retention in A. mellifera, but reduced extinction memory retention in A. cerana. The reasons for these differences are unclear, but provide a basis for future studies to explore species-specific differences in the effects of methylation on memory formation. |
| Keyword | Apis Cerana Apis Mellifera Dna Methylation Acquisition Learning And Memory Extinction Learning And Memory |
| Document Type | 期刊论文 |
| Identifier | https://ir.xtbg.ac.cn/handle/353005/10001 |
| Collection | 2012年后新成立研究组 |
| Recommended Citation GB/T 7714 | Gong, Zhiwen,Wang, Chao,Nieh, James C.,et al. Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera[J]. JOURNAL OF INSECT PHYSIOLOGY,2016,90(x):43-48. |
| APA | Gong, Zhiwen,Wang, Chao,Nieh, James C.,&Tan, Ken.(2016).Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera.JOURNAL OF INSECT PHYSIOLOGY,90(x),43-48. |
| MLA | Gong, Zhiwen,et al."Inhibiting DNA methylation alters olfactory extinction but not acquisition learning in Apis cerana and Apis mellifera".JOURNAL OF INSECT PHYSIOLOGY 90.x(2016):43-48. |
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